Osteoporosis – Cannabis Compound Hardens Bone

One other research paper has just been published that shows how plant based chemical substances can help to develop the brittle bone disease, weak bones. Scientists at the Company of Medical Sciences, College or university of Aberdeen, UK have uncovered how a non-psychoactive compound in cannabis, cannabidiol really helps to maintain bone power. Cannabidiol

The endocannabinoid system is a group of cellular receptors that are stimulated by a group of endogenous lipids as well as compounds derived from the cannabis plant. The cannabinoid receptors take part in a variety of physiological processes including hunger control, pain, memory and mood. Recent studies have shown that the endocannabinoid system also has a strong influence on bone metabolism, as the pain are well represented on osteoclasts – cells whoever principal function is to resorb (thin out) bone.

Bone is the, living tissue that will be consistently formed, remodeled and molded in response to both physical and physiological needs of the body. Bone fragments matrix consists generally of the macronutrients calcium, magnesium (mg) and phosphate and is the material that produces up both the dense regions of the bone and the bone marrow framework. A large number of people still believe if one eats foods abundant with these minerals then they will avoid developing brittle bones. Epidemiological and other proof shows that this is not necessarily the circumstance.

In terms of bone health and disease the integrated techniques that control the development and resorption bone are just as important as the of calcium, magnesium (mg) and phosphate.

The development and resorbtion of bone matrix is handled by two main cell types:

1) Osteoblasts are bone cells that are in charge of the formation of bone matrix
2) Osteoclasts are modified white blood cellular material in charge of the resorption of bone tissue.

The two of these cellular types are handled by a complex set of signaling hormones, proteins and cell receptors that react to the ever-changing needs on bone tissue and other physiological processes. In the event there are very many osteoclasts, or if these cells become overactive, they will resorb more matrix than the osteoblasts will produce. A predominance of osteoclast activity results in the bone becoming less dense – the primary characteristic of the specialized medical condition known as brittle bones.

The Aberdeen researchers have uncovered that cannabidiol binds to a specific cannabinoid receptor on the bone-resorbing osteoblast cells. By so doing it inhibits these cells from resorbing the bone matrix – thus assisting to prevent further deterioration of the bones.

This kind of is not initially that plant compounds have recently been shown to influence bone metabolism in favour of better bones. In January 2009 researchers at Ok State University in the USA found that, even in the occurrence of oxidative stress and systemic inflammation, polyphenols derived from plums inhibit the action of the bone-softening osteoclasts but enhance the technology and process of bone-building osteoblasts.

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